PAR-1 signaling on macrophages is required for effective in vivo delayed-type hypersensitivity responses

PAR-1 signaling on macrophages is required for effective in vivo delayed-type hypersensitivity responses

Summary: Delayed-type hypersensitivity (DTH) responses underpin chronic inflammation. Using a model of oxazolone-induced dermatitis and a combination of transgenic mice, adoptive cell transfer, and selective agonists/antagonists against protease activated receptors, we show that that PAR-1 signaling...

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Bibliographic Details
Main Authors: Hannah Wilkinson, Hugh Leonard, Daxin Chen, Toby Lawrence, Michael Robson, Pieter. Goossens, John H. McVey, Anthony Dorling
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:iScience
Subjects:
Molecular Biology
Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220311780

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http://www.sciencedirect.com/science/article/pii/S2589004220311780

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