Estrogen depletion and drug treatment alter the microstructure of type I collagen in bone

The impact of estrogen depletion and drug treatment on type I collagen fibril nanomorphology and collagen fibril packing (microstructure) was evaluated by atomic force microscopy (AFM) using an ovariectomized (OVX) rabbit model of estrogen deficiency induced bone loss. Nine month-old New Zealand whi...

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Bibliographic Details
Main Authors: Meagan A. Cauble, Matthew J. Muckley, Ming Fang, Jeffrey A. Fessler, Kathleen Welch, Edward D. Rothman, Bradford G. Orr, Le T. Duong, Mark M. Banaszak Holl
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Bone Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S235218721630033X