Nogo-A-deficient transgenic rats show deficits in higher cognitive functions, decreased anxiety and altered circadian activity patterns

Nogo-A-deficient transgenic rats show deficits in higher cognitive functions, decreased anxiety and altered circadian activity patterns

Decreased levels of Nogo-A dependent signaling have been shown to affect behavior and cognitive functions. In Nogo-A knockout and knock-down laboratory rodents, behavioral alterations were observed, possibly corresponding with human neuropsychiatric diseases of neurodevelopmental origin, particularl...

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Bibliographic Details
Main Authors: Tomas ePetrasek, Iva eProkopova, Martin eSladek, Kamila eWeissova, Iveta eVojtechova, Stepan eBahnik, Anna eZemanova, Kai eSchönig, Stefan eBerger, Björn eTews, Dusan eBartsch, Martin eSchwab, Alena eSumova, Ales eStuchlik
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-03-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Anhedonia
Cognition
Spatial learning
Nogo-A
passive avoidance
circadian rhythmicity
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00090/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00090/full

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