Solid-Phase Synthesis of Optically Active Substituted 2 Aminofuranones Using an Activated Carbonate Linker

Solid-Phase Synthesis of Optically Active Substituted 2 Aminofuranones Using an Activated Carbonate Linker

An efficient three-step solid-phase synthesis of diverse 3,5-disubstituted-2-aminofuranones has been developed. α-Hydroxy acids loaded on a nitrophenyl carbonate derivative of Wang resin are used as acylating agents for the C-acylation of active methylene compounds and the resulting intermediates pr...

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Bibliographic Details
Main Authors: Dimitris Matiadis, Kyriakos C. Prousis, Olga Igglessi-Markopoulou
Format: Article
Language:English
Published: MDPI AG 2009-09-01
Series:Molecules
Subjects:
2-aminofuranones
solid-phase synthesis
heterocycles
lactones
acylations
Online Access:http://www.mdpi.com/1420-3049/14/10/3914/

Internet

http://www.mdpi.com/1420-3049/14/10/3914/

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