The L-4F mimetic peptide prevents insulin resistance through increased levels of HO-1, pAMPK, and pAKT in obese mice*1

The L-4F mimetic peptide prevents insulin resistance through increased levels of HO-1, pAMPK, and pAKT in obese mice*1

We examined mechanisms by which L-4F reduces obesity and diabetes in obese (ob) diabetic mice. We hypothesized that L-4F reduces adiposity via increased pAMPK, pAKT, HO-1, and increased insulin receptor phosphorylation in ob mice. Obese and lean mice were divided into five groups: lean, lean-L-4F-tr...

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Bibliographic Details
Main Authors: Stephen J. Peterson, Dong Hyun Kim, Ming Li, Vincenzo Positano, Luca Vanella, Luigi F. Rodella, Francesco Piccolomini, Nitin Puri, Amalia Gastaldelli, Claudia Kusmic, Antonio L’Abbate, Nader G. Abraham
Format: Article
Language:English
Published: Elsevier 2009-07-01
Series:Journal of Lipid Research
Subjects:
diabetes
adiponectin
adiposity
apolipoprotein A-I
heme oxygenase-1
insulin receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520307781

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http://www.sciencedirect.com/science/article/pii/S0022227520307781

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