ENC1 Facilitates Colorectal Carcinoma Tumorigenesis and Metastasis via JAK2/STAT5/AKT Axis-Mediated Epithelial Mesenchymal Transition and Stemness

Ectodermal neural cortex 1 (ENC1) is an actin-binding protein and has been known to be upregulated in several cancers, but the molecular mechanisms through which it contributes to the pathology of CRC have largely been elusive. We utilized data mining and validated the aberrant expression of ENC1, f...

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Bibliographic Details
Main Authors: Ying Cui, Jiani Yang, Yibing Bai, QingWei Li, Yuanfei Yao, Chao Liu, Feng Wu, Jingchun Zhang, Yanqiao Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
CRC
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.616887/full