A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta.

A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta.

Chorioallantoic branching morphogenesis is a key milestone during placental development, creating the large surface area for nutrient and gas exchange, and is therefore critical for the success of term pregnancy. Several Wnt pathway molecules have been shown to regulate placental development. Howeve...

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Bibliographic Details
Main Authors: Jinhua Lu, Shuang Zhang, Haruo Nakano, David G Simmons, Shumin Wang, Shuangbo Kong, Qiang Wang, Lianju Shen, Zhaowei Tu, Weixiang Wang, Bingyan Wang, Hongmei Wang, Yanling Wang, Johan H van Es, Hans Clevers, Gustavo Leone, James C Cross, Haibin Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC3627642?pdf=render

Internet

http://europepmc.org/articles/PMC3627642?pdf=render

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