Inflammatory Phenotype of Intrahepatic Sulfatide-Reactive Type II NKT Cells in Humans With Autoimmune Hepatitis

Inflammatory Phenotype of Intrahepatic Sulfatide-Reactive Type II NKT Cells in Humans With Autoimmune Hepatitis

Background: Natural Killer T (NKT) cells are CD1d-restricted innate-like T cells that can rapidly release stored cytokines upon recognition of lipid antigens. In mice, type I NKT cells seem to promote liver inflammation, whereas type II NKT cells seem to restrict hepatitis. Here, we aimed at charact...

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Bibliographic Details
Main Authors: Marcial Sebode, Jennifer Wigger, Pamela Filpe, Lutz Fischer, Sören Weidemann, Till Krech, Christina Weiler-Normann, Moritz Peiseler, Johannes Hartl, Eva Tolosa, Johannes Herkel, Christoph Schramm, Ansgar W. Lohse, Philomena Arrenberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
alpha-galactosylceramide
CD1d
lipid antigen
tumor necrosis factor-alpha
unconventional T cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01065/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01065/full

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