The NRF2 transcriptional target NQO1 has low mRNA levels in TP53-mutated endometrial carcinomas.

The NRF2 transcriptional target NQO1 has low mRNA levels in TP53-mutated endometrial carcinomas.

BACKGROUND:NRF2 is a major transcription factor regulating the expression of antioxidative/detoxifying enzymes, involved in oncogenic processes and drug resistance. We aimed to identify molecular alterations associated with NRF2 activation in endometrial carcinoma (EC). METHODS:Ninety patients treat...

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Bibliographic Details
Main Authors: Guillaume Beinse, Pierre-Alexandre Just, Bastien Rance, Brigitte Izac, Franck Letourneur, Nathaniel Edward Bennett Saidu, Sandrine Chouzenoux, Carole Nicco, François Goldwasser, Eric Pasmant, Frederic Batteux, Bruno Borghese, Jérôme Alexandre, Karen Leroy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0214416

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https://doi.org/10.1371/journal.pone.0214416

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