Pseudomonas aeruginosa LasB Subverts Alveolar Macrophage Activity by Interfering With Bacterial Killing Through Downregulation of Innate Immune Defense, Reactive Oxygen Species Generation, and Complement Activation

Pseudomonas aeruginosa LasB Subverts Alveolar Macrophage Activity by Interfering With Bacterial Killing Through Downregulation of Innate Immune Defense, Reactive Oxygen Species Generation, and Complement Activation

Pseudomonas aeruginosa (P.a) is a pathogen causing significant morbidity and mortality, in particular, in hospital patients undergoing ventilation and in patients with cystic fibrosis. Among the virulence factors secreted or injected into host cells, the physiopathological relevance of type II secre...

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Bibliographic Details
Main Authors: Fabien Bastaert, Saadé Kheir, Vinciane Saint-Criq, Bérengère Villeret, Pham My-Chan Dang, Jamel El-Benna, Jean-Claude Sirard, Romé Voulhoux, Jean-Michel Sallenave
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
alveolar macrophage
Pseudomonas aeruginosa
LasB
lung
infection
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01675/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01675/full

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