Systematic identification of plausible pathways to potential harm via problem formulation for investigational releases of a population suppression gene drive to control the human malaria vector Anopheles gambiae in West Africa

Systematic identification of plausible pathways to potential harm via problem formulation for investigational releases of a population suppression gene drive to control the human malaria vector Anopheles gambiae in West Africa

Abstract Background Population suppression gene drive has been proposed as a strategy for malaria vector control. A CRISPR-Cas9-based transgene homing at the doublesex locus (dsxF CRISPRh ) has recently been shown to increase rapidly in frequency in, and suppress, caged laboratory populations of the...

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Bibliographic Details
Main Authors: John B. Connolly, John D. Mumford, Silke Fuchs, Geoff Turner, Camilla Beech, Ace R. North, Austin Burt
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Malaria Journal
Subjects:
Gene drive
Population suppression gene drive
Anopheles
Transgenic
Field release
Malaria
Online Access:https://doi.org/10.1186/s12936-021-03674-6

Internet

https://doi.org/10.1186/s12936-021-03674-6

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