Synthesis of the Folylpolyglutamate Synthetase Inhibitor Nα-Pteroyl-Lornithine and its Nδ-Benzoyl and Nδ-Hemiphthaloyl Derivatives, and an Improved Synthesis of Nα-( 4-Amino-4-deoxypteroy1)-Nδ-hemiphthaloyl-Lornithine

N10-Formylpteroic acid may be prepared from folic acid by sequentially heating with formic acid and cleaving the glutamate side chain with carboxypeptidase G1. Condensation of the product with the Nα,O bis( trimethylsilyl) derivative of Nδ-(tert-butyloxycarbonyl)-L-ornithine via a modification of th...

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Bibliographic Details
Main Authors: Rosowsky Andre, Bader Henry, Forsch Ronald A.
Format: Article
Language:English
Published: De Gruyter 1989-05-01
Series:Pteridines
Online Access:https://doi.org/10.1515/pteridines.1989.1.2.91