Bixin Attenuates Experimental Autoimmune Encephalomyelitis by Suppressing TXNIP/NLRP3 Inflammasome Activity and Activating NRF2 Signaling

Bixin Attenuates Experimental Autoimmune Encephalomyelitis by Suppressing TXNIP/NLRP3 Inflammasome Activity and Activating NRF2 Signaling

Multiple sclerosis (MS), an autoimmune and degenerative disease, is characterized by demyelination and chronic neuroinflammation. Bixin is a carotenoid isolated from the seeds of Bixa orellana that exhibits various potent pharmacological activities, including antioxidant, anti-inflammatory, and anti...

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Bibliographic Details
Main Authors:	Ye Yu, Dong-Ming Wu, Jing Li, Shi-Hua Deng, Teng Liu, Ting Zhang, Miao He, Yang-Yang Zhao, Ying Xu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-12-01
Series:	Frontiers in Immunology
Subjects:	bixin experimental autoimmune encephalomyelitis thioredoxin-interacting protein NLRP3 nuclear factor erythroid 2-related factor 2 reactive oxygen species
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2020.593368/full

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