Bixin Attenuates Experimental Autoimmune Encephalomyelitis by Suppressing TXNIP/NLRP3 Inflammasome Activity and Activating NRF2 Signaling

Bixin Attenuates Experimental Autoimmune Encephalomyelitis by Suppressing TXNIP/NLRP3 Inflammasome Activity and Activating NRF2 Signaling

Multiple sclerosis (MS), an autoimmune and degenerative disease, is characterized by demyelination and chronic neuroinflammation. Bixin is a carotenoid isolated from the seeds of Bixa orellana that exhibits various potent pharmacological activities, including antioxidant, anti-inflammatory, and anti...

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Bibliographic Details
Main Authors: Ye Yu, Dong-Ming Wu, Jing Li, Shi-Hua Deng, Teng Liu, Ting Zhang, Miao He, Yang-Yang Zhao, Ying Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
bixin
experimental autoimmune encephalomyelitis
thioredoxin-interacting protein
NLRP3
nuclear factor erythroid 2-related factor 2
reactive oxygen species
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.593368/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.593368/full

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