Investigating β-N-Methylamino-l-alanine Misincorporation in Human Cell Cultures: A Comparative Study with Known Amino Acid Analogues

Misincorporation of β-N-methylamino-l-alanine (BMAA) into proteins has been proposed to be a mechanism of toxicity to explain the role of BMAA in neurodegenerative disease development. However, studies have shown that all detectable BMAA can be removed from proteins by SDS-PAGE purification and that...

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Bibliographic Details
Main Authors: Rianita van Onselen, Simoné Downing, Gabré Kemp, Tim Downing
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:Toxins
Subjects:
Online Access:https://www.mdpi.com/2072-6651/9/12/400