Functional Roles of PARP2 in Assembling Protein–Protein Complexes Involved in Base Excision DNA Repair

Functional Roles of PARP2 in Assembling Protein–Protein Complexes Involved in Base Excision DNA Repair

Poly(ADP-ribose) polymerase 2 (PARP2) participates in base excision repair (BER) alongside PARP1, but its functions are still under study. Here, we characterize binding affinities of PARP2 for other BER proteins (PARP1, APE1, Polβ, and XRCC1) and oligomerization states of the homo- and hetero-associ...

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Bibliographic Details
Main Authors: Inna Vasil’eva, Nina Moor, Rashid Anarbaev, Mikhail Kutuzov, Olga Lavrik
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
PARP2
PARP1
protein–protein interaction
base excision repair
poly(ADP-ribosyl)ation
fluorescence techniques
Online Access:https://www.mdpi.com/1422-0067/22/9/4679

Internet

https://www.mdpi.com/1422-0067/22/9/4679

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