Lentiviral transduction of CD34(+) cells induces genome-wide epigenetic modifications.

Lentiviral transduction of CD34(+) cells induces genome-wide epigenetic modifications.

Epigenetic modifications may occur during in vitro manipulations of stem cells but these effects have remained unexplored in the context of cell and gene therapy protocols. In an experimental model of ex vivo gene modification for hematopoietic gene therapy, human CD34(+) cells were cultured shortly...

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Bibliographic Details
Main Authors: Yoshiaki Yamagata, Véronique Parietti, Daniel Stockholm, Guillaume Corre, Catherine Poinsignon, Nizar Touleimat, Damien Delafoy, Céline Besse, Jörg Tost, Anne Galy, András Paldi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23145033/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23145033/?tool=EBI

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