Exogenous Stimulation of Type I Interferon Protects Mice with Chronic Granulomatous Disease from Aspergillosis through Early Recruitment of Host-Protective Neutrophils into the Lung

Exogenous Stimulation of Type I Interferon Protects Mice with Chronic Granulomatous Disease from Aspergillosis through Early Recruitment of Host-Protective Neutrophils into the Lung

Invasive aspergillosis (IA) remains the primary cause of morbidity and mortality in chronic granulomatous disease (CGD) patients, often due to infection by Aspergillus species refractory to antifungals. This motivates the search for alternative treatments, including immunotherapy. We investigated th...

Full description

Bibliographic Details
Main Authors: Seyedmojtaba Seyedmousavi, Michael J. Davis, Janyce A. Sugui, Tzvia Pinkhasov, Shannon Moyer, Andres M. Salazar, Yun C. Chang, Kyung J. Kwon-Chung, J. Andrew Alspaugh
Format: Article
Language:English
Published: American Society for Microbiology 2018-03-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/9/2/e00422-18

Internet

http://mbio.asm.org/cgi/content/full/9/2/e00422-18

Similar Items