Inhibition of Spinal Oxidative Stress by Bergamot Polyphenolic Fraction Attenuates the Development of Morphine Induced Tolerance and Hyperalgesia in Mice.

Citrus Bergamia Risso, commonly known as Bergamot, is a fruit whose Essential Oil and Bergamot Polyphenolic Fraction have numerous medicinal properties. It is also an excellent antioxidant and in this study, for the first time, its potential effect on morphine induced tolerance in mice has been inve...

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Main Authors: Filomena Lauro, Luigino Antonio Giancotti, Sara Ilari, Concetta Dagostino, Micaela Gliozzi, Chiara Morabito, Valentina Malafoglia, William Raffaeli, Maurizio Muraca, Bianca M Goffredo, Vincenzo Mollace, Carolina Muscoli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4881894?pdf=render