EP3 Blockade Adds to the Effect of TP Deficiency in Alleviating Endothelial Dysfunction in Atherosclerotic Mouse Aortas

EP3 Blockade Adds to the Effect of TP Deficiency in Alleviating Endothelial Dysfunction in Atherosclerotic Mouse Aortas

Endothelial dysfunction, which leads to ischemic events under atherosclerotic conditions, can be attenuated by antagonizing the thromboxane-prostanoid receptor (TP) that mediates the vasoconstrictor effect of prostanoids including prostacyclin (PGI2). This study aimed to determine whether antagonizi...

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Bibliographic Details
Main Authors: Chuangjia Hu, Bin Liu, Yineng Xu, Xiangzhong Wu, Tingting Guo, Yingzhan Zhang, Jing Leng, Jiahui Ge, Gang Yu, Jinwei Guo, Yingbi Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Physiology
Subjects:
PGI2
prostanoid receptors
endothelium
relaxation
contraction
atherosclerosis
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01247/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.01247/full

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