IL-17A Neutralization Improves the Neurological Outcome of Mice With Ischemic Stroke and Inhibits Caspase-12-Dependent Apoptosis

IL-17A Neutralization Improves the Neurological Outcome of Mice With Ischemic Stroke and Inhibits Caspase-12-Dependent Apoptosis

We previously reported that the levels of astrocyte-derived interleukin-17A (IL-17A) increased both in the peri-infarct region and cerebrospinal fluid (CSF) of mice with 1-h middle cerebral artery (MCA) occlusion/12-h reperfusion (1-h MCAO/R 12 h)-induced ischemic stroke. However, the effects of IL-...

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Bibliographic Details
Main Authors: Qingqing Dai, Song Han, Ting Liu, Jiayin Zheng, Cui Liu, Junfa Li, Shujuan Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Aging Neuroscience
Subjects:
interleukin-17A neutralization
neuronal apoptosis
oxygen–glucose deprivation (OGD)
middle cerebral artery occlusion (MCAO)
casepase-12
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2020.00274/full

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https://www.frontiersin.org/article/10.3389/fnagi.2020.00274/full

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