Astrocyte-derived Jagged-1 mitigates deleterious Notch signaling in amyotrophic lateral sclerosis

Astrocyte-derived Jagged-1 mitigates deleterious Notch signaling in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a late-onset devastating degenerative disease mainly affecting motor neurons. Motor neuron degeneration is accompanied and aggravated by oligodendroglial pathology and the presence of reactive astrocytes and microglia. We studied the role of the Notch signaling...

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Bibliographic Details
Main Authors: Annelies Nonneman, Nathan Criem, Sebastian A. Lewandowski, Rik Nuyts, Dietmar R. Thal, Frank W. Pfrieger, John Ravits, Philip Van Damme, An Zwijsen, Ludo Van Den Bosch, Wim Robberecht
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis
Notch
Jagged-1
Cis
Trans
Astrocyte
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118302493

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