Enhanced target cell specificity and uptake of lipid nanoparticles using RNA aptamers and peptides

Enhanced target cell specificity and uptake of lipid nanoparticles using RNA aptamers and peptides

Lipid nanoparticles (LNPs) constitute a facile and scalable approach for delivery of payloads to human cells. LNPs are relatively immunologically inert and can be produced in a cost effective and scalable manner. However, targeting and delivery of LNPs across the blood–brain barrier (BBB) has proven...

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Bibliographic Details
Main Authors: Roslyn M. Ray, Anders Højgaard Hansen, Maria Taskova, Bernhard Jandl, Jonas Hansen, Citra Soemardy, Kevin V. Morris, Kira Astakhova
Format: Article
Language:English
Published: Beilstein-Institut 2021-04-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
aptamer
blood–brain barrier
gene therapy
hiv-1
lipid nanoparticle
Online Access:https://doi.org/10.3762/bjoc.17.75

Internet

https://doi.org/10.3762/bjoc.17.75

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