GLP-1 Receptor Activation Abrogates β-Cell Dysfunction by PKA Cα-Mediated Degradation of Thioredoxin Interacting Protein

GLP-1 Receptor Activation Abrogates β-Cell Dysfunction by PKA Cα-Mediated Degradation of Thioredoxin Interacting Protein

Glucagon-like peptide 1 receptor (GLP-1R) agonist (Exendin-4) is a well-known agent used to improve β-cell dysfunctions via protein kinase A (PKA), but the detailed downstream molecular mechanisms are still elusive. We have now found that PKA Cα mediated- TXNIP phosphorylation and degradation played...

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Bibliographic Details
Main Authors: Shijun He, Wenyu Wu, Yihong Wan, Kutty Selva Nandakumar, Xiuchao Cai, Xiaodong Tang, Shuwen Liu, Xingang Yao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Pharmacology
Subjects:
exendin 4
PKA
Pancreatic beta cells
er stress
beta cell dysfunction
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01230/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01230/full

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