Adult neurogenesis is functionally associated with AD-like neurodegeneration

Adult neurogenesis is functionally associated with AD-like neurodegeneration

Alzheimer's disease (AD) is predominantly characterized by progressive neuronal loss in the brain. It has been recently found that adult neurogenesis in the hippocampal dentate gyrus of AD patients is significantly enhanced, while its functional significance is still unknown. By using an AD-lik...

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Bibliographic Details
Main Authors: Qian Chen, Akira Nakajima, Se Hoon Choi, Xiaoli Xiong, Sangram S. Sisodia, Ya-Ping Tang
Format: Article
Language:English
Published: Elsevier 2008-02-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Adult neurogenesis
Neuronal loss
Presenilin 1
Neurodegeneration
Conditional knockout
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107002215

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http://www.sciencedirect.com/science/article/pii/S0969996107002215

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