Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion
Chronic antiretroviral therapy does not eradicate HIV infection. Here, the authors describe a potentially one-shot alternative by engineering B cells to express anti-HIV antibodies and undergo memory retention, isotype switching and clonal expansion
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2020-11-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-19649-1 |
| id |
doaj-53cea78635c1437b9150abc735992dd8 |
|---|---|
| record_format |
Article |
| spelling |
doaj-53cea78635c1437b9150abc735992dd82021-05-11T09:10:37ZengNature Publishing GroupNature Communications2041-17232020-11-0111111010.1038/s41467-020-19649-1Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansionAlessio D. Nahmad0Yuval Raviv1Miriam Horovitz-Fried2Ilan Sofer3Tal Akriv4Daniel Nataf5Iris Dotan6Yaron Carmi7David Burstein8Yariv Wine9Itai Benhar10Adi Barzel11The School of Neurobiology, Biochemistry and Biophysics, The George S. Wise Faculty of Life Sciences, Tel Aviv UniversityThe School of Neurobiology, Biochemistry and Biophysics, The George S. Wise Faculty of Life Sciences, Tel Aviv UniversityThe School of Neurobiology, Biochemistry and Biophysics, The George S. Wise Faculty of Life Sciences, Tel Aviv UniversityThe School of Neurobiology, Biochemistry and Biophysics, The George S. Wise Faculty of Life Sciences, Tel Aviv UniversityThe School of Neurobiology, Biochemistry and Biophysics, The George S. Wise Faculty of Life Sciences, Tel Aviv UniversityThe School of Neurobiology, Biochemistry and Biophysics, The George S. Wise Faculty of Life Sciences, Tel Aviv UniversityThe School of Neurobiology, Biochemistry and Biophysics, The George S. Wise Faculty of Life Sciences, Tel Aviv UniversityDepartment of Pathology, The Sackler School of Medicine, Tel Aviv UniversityThe School of Molecular Cell Biology and Biotechnology, The George S. Wise Faculty of Life Sciences, Tel Aviv UniversityThe School of Molecular Cell Biology and Biotechnology, The George S. Wise Faculty of Life Sciences, Tel Aviv UniversityThe School of Molecular Cell Biology and Biotechnology, The George S. Wise Faculty of Life Sciences, Tel Aviv UniversityThe School of Neurobiology, Biochemistry and Biophysics, The George S. Wise Faculty of Life Sciences, Tel Aviv UniversityChronic antiretroviral therapy does not eradicate HIV infection. Here, the authors describe a potentially one-shot alternative by engineering B cells to express anti-HIV antibodies and undergo memory retention, isotype switching and clonal expansionhttps://doi.org/10.1038/s41467-020-19649-1 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Alessio D. Nahmad Yuval Raviv Miriam Horovitz-Fried Ilan Sofer Tal Akriv Daniel Nataf Iris Dotan Yaron Carmi David Burstein Yariv Wine Itai Benhar Adi Barzel |
| spellingShingle |
Alessio D. Nahmad Yuval Raviv Miriam Horovitz-Fried Ilan Sofer Tal Akriv Daniel Nataf Iris Dotan Yaron Carmi David Burstein Yariv Wine Itai Benhar Adi Barzel Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion Nature Communications |
| author_facet |
Alessio D. Nahmad Yuval Raviv Miriam Horovitz-Fried Ilan Sofer Tal Akriv Daniel Nataf Iris Dotan Yaron Carmi David Burstein Yariv Wine Itai Benhar Adi Barzel |
| author_sort |
Alessio D. Nahmad |
| title |
Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion |
| title_short |
Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion |
| title_full |
Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion |
| title_fullStr |
Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion |
| title_full_unstemmed |
Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion |
| title_sort |
engineered b cells expressing an anti-hiv antibody enable memory retention, isotype switching and clonal expansion |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-11-01 |
| description |
Chronic antiretroviral therapy does not eradicate HIV infection. Here, the authors describe a potentially one-shot alternative by engineering B cells to express anti-HIV antibodies and undergo memory retention, isotype switching and clonal expansion |
| url |
https://doi.org/10.1038/s41467-020-19649-1 |
| work_keys_str_mv |
AT alessiodnahmad engineeredbcellsexpressinganantihivantibodyenablememoryretentionisotypeswitchingandclonalexpansion AT yuvalraviv engineeredbcellsexpressinganantihivantibodyenablememoryretentionisotypeswitchingandclonalexpansion AT miriamhorovitzfried engineeredbcellsexpressinganantihivantibodyenablememoryretentionisotypeswitchingandclonalexpansion AT ilansofer engineeredbcellsexpressinganantihivantibodyenablememoryretentionisotypeswitchingandclonalexpansion AT talakriv engineeredbcellsexpressinganantihivantibodyenablememoryretentionisotypeswitchingandclonalexpansion AT danielnataf engineeredbcellsexpressinganantihivantibodyenablememoryretentionisotypeswitchingandclonalexpansion AT irisdotan engineeredbcellsexpressinganantihivantibodyenablememoryretentionisotypeswitchingandclonalexpansion AT yaroncarmi engineeredbcellsexpressinganantihivantibodyenablememoryretentionisotypeswitchingandclonalexpansion AT davidburstein engineeredbcellsexpressinganantihivantibodyenablememoryretentionisotypeswitchingandclonalexpansion AT yarivwine engineeredbcellsexpressinganantihivantibodyenablememoryretentionisotypeswitchingandclonalexpansion AT itaibenhar engineeredbcellsexpressinganantihivantibodyenablememoryretentionisotypeswitchingandclonalexpansion AT adibarzel engineeredbcellsexpressinganantihivantibodyenablememoryretentionisotypeswitchingandclonalexpansion |
| _version_ |
1721450092253151232 |