Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion

Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion

Chronic antiretroviral therapy does not eradicate HIV infection. Here, the authors describe a potentially one-shot alternative by engineering B cells to express anti-HIV antibodies and undergo memory retention, isotype switching and clonal expansion

Bibliographic Details
Main Authors: Alessio D. Nahmad, Yuval Raviv, Miriam Horovitz-Fried, Ilan Sofer, Tal Akriv, Daniel Nataf, Iris Dotan, Yaron Carmi, David Burstein, Yariv Wine, Itai Benhar, Adi Barzel
Format: Article
Language:English
Published: Nature Publishing Group 2020-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19649-1

Internet

https://doi.org/10.1038/s41467-020-19649-1

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