Age-related effects of dexmedetomidine on myocardial contraction and coronary circulation in isolated guinea pig hearts

Age-related effects of dexmedetomidine on myocardial contraction and coronary circulation in isolated guinea pig hearts

Dexmedetomidine is a selective α2 adrenergic agonist. Although dexmedetomidine is widely used for sedation and analgesia, it frequently produces hypotension and bradycardia. The present study aimed to evaluate the effects of dexmedetomidine on cardiac function and coronary circulation using Langendo...

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Bibliographic Details
Main Authors: Maiko Hongo, Susumu Fujisawa, Takeshi Adachi, Tomonori Shimbo, Shigehiro Shibata, Takayoshi Ohba, Kyoichi Ono
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Journal of Pharmacological Sciences
Subjects:
Dexmedetomidine
Cardiac function
Coronary circulation
α2-adrenoceptor
Langendorff perfusion
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861316300548

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http://www.sciencedirect.com/science/article/pii/S1347861316300548

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