β-Nicotinamide Adenine Dinucleotide (β-NAD) Inhibits ATP-Dependent IL-1β Release from Human Monocytic Cells

β-Nicotinamide Adenine Dinucleotide (β-NAD) Inhibits ATP-Dependent IL-1β Release from Human Monocytic Cells

While interleukin-1β (IL-1β) is a potent pro-inflammatory cytokine essential for host defense, high systemic levels cause life-threatening inflammatory syndromes. ATP, a stimulus of IL-1β maturation, is released from damaged cells along with β-nicotinamide adenine dinucleotide (β-NAD). Here, we test...

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Bibliographic Details
Main Authors: Sebastian Daniel Hiller, Sarah Heldmann, Katrin Richter, Innokentij Jurastow, Mira Küllmar, Andreas Hecker, Sigrid Wilker, Gabriele Fuchs-Moll, Ivan Manzini, Günther Schmalzing, Wolfgang Kummer, Winfried Padberg, J. Michael McIntosh, Jelena Damm, Anna Zakrzewicz, Veronika Grau
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:International Journal of Molecular Sciences
Subjects:
β-NAD
β-nicotinamide adenine dinucleotide
CHRNA7
CHRNA9
CHRNA10
inflammasome
interleukin-1β
iPLA2β
monocyte
P2RY1
P2RY11
PLA2G6
U937 cells
Online Access:http://www.mdpi.com/1422-0067/19/4/1126

Internet

http://www.mdpi.com/1422-0067/19/4/1126

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