Membrane Localization of HspA1A, a Stress Inducible 70-kDa Heat-Shock Protein, Depends on Its Interaction with Intracellular Phosphatidylserine

HspA1A is a cytosolic molecular chaperone essential for cellular homeostasis. HspA1A also localizes at the plasma membrane (PM) of tumor and stressed cells. However, it is currently unknown how this cytosolic protein translocates to the PM. Taking into account that HspA1A interacts with lipids, incl...

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Bibliographic Details
Main Authors: Andrei D. Bilog, Larissa Smulders, Ryan Oliverio, Cedra Labanieh, Julianne Zapanta, Robert V. Stahelin, Nikolas Nikolaidis
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Biomolecules
Subjects:
Online Access:https://www.mdpi.com/2218-273X/9/4/152