Acute but not chronic metabolic acidosis potentiates the acetylcholine-induced reduction in blood pressure: an endothelium-dependent effect

Acute but not chronic metabolic acidosis potentiates the acetylcholine-induced reduction in blood pressure: an endothelium-dependent effect

Metabolic acidosis has profound effects on vascular tone. This study investigated the in vivo effects of acute metabolic acidosis (AMA) and chronic metabolic acidosis (CMA) on hemodynamic parameters and endothelial function. CMA was induced by ad libitum intake of 1% NH4Cl for 7 days, and AMA was in...

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Bibliographic Details
Main Authors: A.C. Celotto, L.G. Ferreira, V.K. Capellini, A.A.S. Albuquerque, A.J. Rodrigues, P.R.B. Evora
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2016-01-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Acid-base balance
Metabolic acidosis
Hemodynamic failure
Endothelium
Nitric oxide
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000200604&lng=en&tlng=en

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000200604&lng=en&tlng=en

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