Acetylcholinesterase-Positive Fiber Deafferentation and Cell Shrinkage in the Septohippocampal Pathway of Aged Amyloid Precursor Protein London Mutant Transgenic Mice

Acetylcholinesterase-Positive Fiber Deafferentation and Cell Shrinkage in the Septohippocampal Pathway of Aged Amyloid Precursor Protein London Mutant Transgenic Mice

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Several lines of evidence implicate a cholinergic deficit in Alzheimer's disease (AD). Transgenic mice that overexpress clinical mutants of the human amyloid precursor protein (APP) have been generated that recapitulate many aspects of AD. We now analyzed the cholinergic system in aged APP/Lond...

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Bibliographic Details
Main Authors: Francisca C. Bronfman, Dieder Moechars, Fred Van Leuven
Format: Article
Language:English
Published: Elsevier 2000-06-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
transgenic mice models
cholinergic system
aging
amyloid plaques
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996100902833

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http://www.sciencedirect.com/science/article/pii/S0969996100902833

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