NOVA2-mediated RNA regulation is required for axonal pathfinding during development

NOVA2-mediated RNA regulation is required for axonal pathfinding during development

The neuron specific RNA-binding proteins NOVA1 and NOVA2 are highly homologous alternative splicing regulators. NOVA proteins regulate at least 700 alternative splicing events in vivo, yet relatively little is known about the biologic consequences of NOVA action and in particular about functional di...

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Bibliographic Details
Main Authors: Yuhki Saito, Soledad Miranda-Rottmann, Matteo Ruggiu, Christopher Y Park, John J Fak, Ru Zhong, Jeremy S Duncan, Brian A Fabella, Harald J Junge, Zhe Chen, Roberto Araya, Bernd Fritzsch, A J Hudspeth, Robert B Darnell
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-05-01
Series:eLife
Subjects:
HITS-CLIP
NOVA
splicing
axon guidance
RNA-seq
agenesis corpus callosum
Online Access:https://elifesciences.org/articles/14371

Internet

https://elifesciences.org/articles/14371

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