Evidence for a novel overlapping coding sequence in POLG initiated at a CUG start codon

Evidence for a novel overlapping coding sequence in POLG initiated at a CUG start codon

Abstract Background POLG, located on nuclear chromosome 15, encodes the DNA polymerase γ(Pol γ). Pol γ is responsible for the replication and repair of mitochondrial DNA (mtDNA). Pol γ is the only DNA polymerase found in mitochondria for most animal cells. Mutations in POLG are the most common singl...

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Bibliographic Details
Main Authors: Yousuf A. Khan, Irwin Jungreis, James C. Wright, Jonathan M. Mudge, Jyoti S. Choudhary, Andrew E. Firth, Manolis Kellis
Format: Article
Language:English
Published: BMC 2020-03-01
Series:BMC Genetics
Subjects:
POLG
CUG
Initiation
Ribosome
Polymerase
Mitochondria
Online Access:http://link.springer.com/article/10.1186/s12863-020-0828-7

Internet

http://link.springer.com/article/10.1186/s12863-020-0828-7

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