GM604 regulates developmental neurogenesis pathways and the expression of genes associated with amyotrophic lateral sclerosis

GM604 regulates developmental neurogenesis pathways and the expression of genes associated with amyotrophic lateral sclerosis

Abstract Background Amyotrophic lateral sclerosis (ALS) is currently an incurable disease without highly effective pharmacological treatments. The peptide drug GM604 (GM6 or Alirinetide) was developed as a candidate ALS therapy, which has demonstrated safety and good drug-like properties with a favo...

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Bibliographic Details
Main Authors: William R. Swindell, Krzysztof Bojanowski, Mark S. Kindy, Raymond M. W. Chau, Dorothy Ko
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Translational Neurodegeneration
Subjects:
Alzheimer’s disease
Amyotrophic lateral sclerosis
Extracellular matrix
Hedgehog
Huntington’s disease
Neurodegenerative disease
Online Access:http://link.springer.com/article/10.1186/s40035-018-0135-7

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http://link.springer.com/article/10.1186/s40035-018-0135-7

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