Natural Killer Cell Degranulation Defect: A Cause for Impaired NK-Cell Cytotoxicity and Hyperinflammation in Fanconi Anemia Patients

Natural Killer Cell Degranulation Defect: A Cause for Impaired NK-Cell Cytotoxicity and Hyperinflammation in Fanconi Anemia Patients

Fanconi anemia (FA) is a rare inherited syndrome characterized by progressive bone marrow failure (BMF), abnormal skin pigmentation, short stature, and increased cancer risk. BMF in FA is multifactorial and largely results from the death of hematopoietic stem cells due to genomic instability. Also,...

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Bibliographic Details
Main Authors: Snehal Shabrish, Madhura Kelkar, Niranjan Chavan, Mukesh Desai, Umair Bargir, Maya Gupta, Priti Mehta, Akanksha Chichra, Chandrakala S, Prasad Taur, Vinay Saxena, Babu Rao Vundinti, Manisha Madkaikar
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
Fanconi anemia
NK cell degranulation defect
Familial Hemophagocytic lymphohistiocytosis (FHL)
HLH-targeted therapy
NK cell cytotoxicity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00490/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00490/full

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