The Low Molecular Weight Heparin Tinzaparin Attenuates Platelet Activation in Terms of Metastatic Niche Formation by Coagulation-Dependent and Independent Pathways

The Low Molecular Weight Heparin Tinzaparin Attenuates Platelet Activation in Terms of Metastatic Niche Formation by Coagulation-Dependent and Independent Pathways

An intimate interplay with platelets is an initial key issue for tumor cells in terms of hematogenous metastasis. Tumor cells activate platelets by different pathways and receive, upon forming a platelet cloak, protection from immune surveillance and support in metastatic niche creation. Therapeutic...

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Bibliographic Details
Main Authors: Lukas Maria Gockel, Jan Moritz Ponert, Svenja Schwarz, Martin Schlesinger, Gerd Bendas
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Molecules
Subjects:
metastatic niche
heparin
platelet
thrombin
tumor
VEGF
Online Access:https://www.mdpi.com/1420-3049/23/11/2753

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