Rational modulation of the innate immune system for neuroprotection in ischemic stroke

Rational modulation of the innate immune system for neuroprotection in ischemic stroke

The innate immune system plays a dualistic role in the evolution of ischemic brain damage and has also been implicated in ischemic tolerance produced by different conditioning stimuli. Early after ischemia, perivascular astrocytes release cytokines and activate metalloproteases (MMPs) that contribut...

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Bibliographic Details
Main Authors: Diana eAmantea, Giuseppe eMicieli, Cristina eTassorelli, Maria I Cuartero, Ivan eBallesteros, Michelangelo eCerto, Maria A Moro, Ignacio eLizasoain, Giacinto eBagetta
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Neuroscience
Subjects:
Cytokines
Immune System
Macrophages
Neutrophils
ischemic stroke
Ischemic tolerance
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00147/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00147/full

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