Neuregulin-1 attenuates experimental cerebral malaria (ECM) pathogenesis by regulating ErbB4/AKT/STAT3 signaling

Neuregulin-1 attenuates experimental cerebral malaria (ECM) pathogenesis by regulating ErbB4/AKT/STAT3 signaling

Abstract Background Human cerebral malaria (HCM) is a severe form of malaria characterized by sequestration of infected erythrocytes (IRBCs) in brain microvessels, increased levels of circulating free heme and pro-inflammatory cytokines and chemokines, brain swelling, vascular dysfunction, coma, and...

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Bibliographic Details
Main Authors: Mingli Liu, Wesley Solomon, Juan Carlos Cespedes, Nana O. Wilson, Byron Ford, Jonathan K. Stiles
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Journal of Neuroinflammation
Subjects:
Cerebral malaria (CM)
Neuregulin-1 (NRG-1)
ErbB4
STAT3
AKT
P. berghei ANKA (PbA)
Online Access:http://link.springer.com/article/10.1186/s12974-018-1147-z

Internet

http://link.springer.com/article/10.1186/s12974-018-1147-z

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