Damage sensing by a Nox-Ask1-MKK3-p38 signaling pathway mediates regeneration in the adult Drosophila midgut

Damage sensing by a Nox-Ask1-MKK3-p38 signaling pathway mediates regeneration in the adult Drosophila midgut

Epithelia are exposed to diverse types of environmental stress, but the mechanisms by which epithelial cells sense stress are not well understood. Here, the authors show that a Nox-ROS-Ask1-MKK3-p38 signaling axis integrates various types of stress to promote intestinal regeneration.

Bibliographic Details
Main Authors: Parthive H. Patel, Clothilde Pénalva, Michael Kardorff, Marianne Roca, Bojana Pavlović, Anja Thiel, Aurelio A. Teleman, Bruce A. Edgar
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12336-w

Internet

https://doi.org/10.1038/s41467-019-12336-w

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