Acetylcholine Inhibits LPS-Induced MMP-9 Production and Cell Migration via the a7 nAChR-JAK2/STAT3 Pathway in RAW264.7 Cells

Acetylcholine Inhibits LPS-Induced MMP-9 Production and Cell Migration via the a7 nAChR-JAK2/STAT3 Pathway in RAW264.7 Cells

Background: Excessive activation of matrix metalloproteinase 9 (MMP-9) has been found in several inflammatory diseases. Previous studies have shown that acetylcholine (ACh) reduced the levels of pro-inflammatory cytokines and decreased tissue damage. Therefore, this study was designed to explore the...

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Bibliographic Details
Main Authors: Yong-Hua Yang, Dong-Ling Li, Xue-Yuan Bi, Lei Sun, Xiao-Jiang Yu, Huan-Le Fang, Yi Miao, Ming Zhao, Xi He, Jin-Jun Liu, Wei-Jin Zang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
α7 nAChR
Acetylcholine
Macrophage
MMP-9
Migration
Online Access:http://www.karger.com/Article/FullText/430170

Internet

http://www.karger.com/Article/FullText/430170

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