Cascade Ligand- and Structure-Based Virtual Screening to Identify New Trypanocidal Compounds Inhibiting Putrescine Uptake

Cascade Ligand- and Structure-Based Virtual Screening to Identify New Trypanocidal Compounds Inhibiting Putrescine Uptake

Chagas disease is a neglected tropical disease endemic to Latin America, though migratory movements have recently spread it to other regions. Here, we have applied a cascade virtual screening campaign combining ligand- and structure-based methods. In order to find novel inhibitors of putrescine upta...

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Bibliographic Details
Main Authors: Lucas N. Alberca, María L. Sbaraglini, Juan F. Morales, Roque Dietrich, María D. Ruiz, Agustina M. Pino Martínez, Cristian G. Miranda, Laura Fraccaroli, Catalina D. Alba Soto, Carolina Carrillo, Pablo H. Palestro, Alan Talevi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Chagas disease
Trypanosoma cruzi
putrescine uptake
drug repositioning
drug repurposing
cinnarizine
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2018.00173/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2018.00173/full

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