Synthesis of Polyheterocyclic Dimers Containing Restricted and Constrained Peptidomimetics via IMCR-Based Domino/Double CuAAC Click Strategy

Synthesis of Polyheterocyclic Dimers Containing Restricted and Constrained Peptidomimetics via IMCR-Based Domino/Double CuAAC Click Strategy

A novel strategy via the triple process (multicomponent reactions (MCR)-domino)/tandem was developed for the synthesis of restricted and constrained bis-1,2,3-triazole-linked pyrrolo[3,4-<i>b</i>]pyridine peptidomimetics dimers in overall yields of 20–55%. This strategy allows the constr...

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Bibliographic Details
Main Authors: Shrikant G. Pharande, Manuel A. Rentería-Gómez, Rocío Gámez-Montaño
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Molecules
Subjects:
isocyanide-based multicomponent reactions
IMCR-based domino and tandem process
CuAAC click
polyheterocyclic dimers
restricted and constrained peptidomimetics
Online Access:https://www.mdpi.com/1420-3049/25/22/5246

Internet

https://www.mdpi.com/1420-3049/25/22/5246

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