Mechanistic modelling of tyrosine recombination reveals key parameters determining the performance of a CAR T cell switching circuit

Mechanistic modelling of tyrosine recombination reveals key parameters determining the performance of a CAR T cell switching circuit

Inducible genetic switches based on tyrosine recombinase-based DNA excision are a promising platform for the regulation and control of chimeric antigen receptor (CAR) T cell activity in cancer immunotherapy. These switches exploit the increased stability of DNA excision in tyrosine recombinases thro...

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Bibliographic Details
Main Authors: Jack E. Bowyer, Deboki Chakravarti, Wilson W. Wong, Declan G. Bates
Format: Article
Language:English
Published: Wiley 2020-02-01
Series:Engineering Biology
Subjects:
molecular biophysics
gene therapy
biochemistry
drugs
genetic engineering
biomedical materials
tumours
dna
enzymes
cancer
cellular biophysics
statistical approximation approaches
system parameters
optimal switch performance
switching response
inducer drug 4-oht
flpo recombinase
mechanistic modelling
tyrosine recombination
car t cell
inducible genetic switches
tyrosine recombinase-based dna excision
chimeric antigen receptor t cell activity
cancer immunotherapy
increased stability
tyrosine recombinases
inversion–excision circuit design
mechanistic mathematical model
Online Access:https://digital-library.theiet.org/content/journals/10.1049/enb.2019.0020

Internet

https://digital-library.theiet.org/content/journals/10.1049/enb.2019.0020

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