Functional instability allows access to DNA in longer transcription Activator-Like effector (TALE) arrays

Functional instability allows access to DNA in longer transcription Activator-Like effector (TALE) arrays

Transcription activator-like effectors (TALEs) bind DNA through an array of tandem 34-residue repeats. How TALE repeat domains wrap around DNA, often extending more than 1.5 helical turns, without using external energy is not well understood. Here, we examine the kinetics of DNA binding of TALE arra...

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Bibliographic Details
Main Authors: Kathryn Geiger-Schuller, Jaba Mitra, Taekjip Ha, Doug Barrick
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-02-01
Series:eLife
Subjects:
TALE repeat
single-molecule biophysics
FRET
functional instability
deterministic modeling
Online Access:https://elifesciences.org/articles/38298

Internet

https://elifesciences.org/articles/38298

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