Everolimus and sirolimus in combination with cyclosporine have different effects on renal metabolism in the rat.

Everolimus and sirolimus in combination with cyclosporine have different effects on renal metabolism in the rat.

Enhancement of calcineurin inhibitor nephrotoxicity by sirolimus (SRL) is limiting the clinical use of this drug combination. We compared the dose-dependent effects of the structurally related everolimus (EVL) and sirolimus (SRL) alone, and in combination with cyclosporine (CsA), on the rat kidney....

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Main Authors: Rahul Bohra, Wenzel Schöning, Jelena Klawitter, Nina Brunner, Volker Schmitz, Touraj Shokati, Ryan Lawrence, Maria Fernanda Arbelaez, Björn Schniedewind, Uwe Christians, Jost Klawitter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3485290?pdf=render

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http://europepmc.org/articles/PMC3485290?pdf=render

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