The structure and dynamics of secretory component and its interactions with polymeric immunoglobulins

The structure and dynamics of secretory component and its interactions with polymeric immunoglobulins

As a first-line vertebrate immune defense, the polymeric immunoglobulin receptor (pIgR) transports polymeric IgA and IgM across epithelia to mucosal secretions, where the cleaved ectodomain (secretory component; SC) becomes a component of secretory antibodies, or when unliganded, binds and excludes...

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Bibliographic Details
Main Authors: Beth M Stadtmueller, Kathryn E Huey-Tubman, Carlos J López, Zhongyu Yang, Wayne L Hubbell, Pamela J Bjorkman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-03-01
Series:eLife
Subjects:
polymeric ig receptor (pIgR)
secretory component (SC)
secretory igA/igM
crystal structures
double electron-electron resonance
surface plasmon resonance
Online Access:https://elifesciences.org/articles/10640

Internet

https://elifesciences.org/articles/10640

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