Deoxyribonuclease 1-Mediated Clearance of Circulating Chromatin Prevents From Immune Cell Activation and Pro-inflammatory Cytokine Production, a Phenomenon Amplified by Low Trap1 Activity: Consequences for Systemic Lupus Erythematosus

Deoxyribonuclease 1-Mediated Clearance of Circulating Chromatin Prevents From Immune Cell Activation and Pro-inflammatory Cytokine Production, a Phenomenon Amplified by Low Trap1 Activity: Consequences for Systemic Lupus Erythematosus

Increased concentrations of circulating chromatin, especially oligo-nucleosomes, are observed in sepsis, cancer and some inflammatory autoimmune diseases like systemic lupus erythematosus (SLE). In SLE, circulating nucleosomes mainly result from increased apoptosis and decreased clearance of apoptot...

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Bibliographic Details
Main Authors: Jasmin Felux, Annika Erbacher, Magali Breckler, Roxane Hervé, Delphine Lemeiter, Hans Georg Mannherz, Markus Napirei, Hans-Georg Rammensee, Patrice Decker
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
DNase1
TRAP1
extracellular chromatin
clearance
inflammation
lupus
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.613597/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.613597/full

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