Spontaneous seizure and partial lethality of juvenile Shank3-overexpressing mice in C57BL/6 J background

Spontaneous seizure and partial lethality of juvenile Shank3-overexpressing mice in C57BL/6 J background

Abstract The SH3 and multiple ankyrin repeat domains 3 (SHANK3) gene encodes core scaffolds in neuronal excitatory postsynapses. SHANK3 duplications have been identified in patients with hyperkinetic disorders and early-onset generalized tonic-clonic seizures. Consistently, Shank3 transgenic (TG) mi...

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Bibliographic Details
Main Authors: Chunmei Jin, Yinhua Zhang, Shinhyun Kim, Yoonhee Kim, Yeunkum Lee, Kihoon Han
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Molecular Brain
Subjects:
Shank3 overexpression
Spontaneous seizure
Lethality
Juvenile stage
Online Access:http://link.springer.com/article/10.1186/s13041-018-0403-6

Internet

http://link.springer.com/article/10.1186/s13041-018-0403-6

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