Metformin and insulin treatment prevent placental telomere attrition in boys exposed to maternal diabetes.

Metformin and insulin treatment prevent placental telomere attrition in boys exposed to maternal diabetes.

Shortened leukocyte and placental telomeres associated with gestational diabetes mellitus (GDM) suggest this exposure triggers telomere attrition contributing to adverse outcomes. We applied high resolution Single Telomere Length Analysis (STELA) to placenta from GDM pregnancies with different treat...

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Bibliographic Details
Main Authors: Isabel Garcia-Martin, Richard J A Penketh, Anna B Janssen, Rhiannon E Jones, Julia Grimstead, Duncan M Baird, Rosalind M John
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0208533

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https://doi.org/10.1371/journal.pone.0208533

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